Project 1. Investigating lineage heterogeneity and the role of unique progenitor cell populations in the development and regenerative potential of the mandibular condyle. We aim to understand the identity of cell populations that reside and contribute to the formation and repair of the temporomandibular joint (TMJ). We will also study the role of the microenvironment (i.e., niche) in the maintenance and differentiation of mandibular condyle progenitor cells.
Project 2. Understanding the pathophysiological mechanisms of mandibular joint osteoarthritis (OA). We seek to identify the pathogenic drivers of TMJ-OA and the consequence of disease states on mandibular condyle progenitor cell populations. In addition, we aim to determine how cell-matrix interactions regulate OA progression.
Project 3. Identifying drivers of temporomandibular disorders (TMDs) using single-cell multiomic approaches. We will use single-cell transcriptomics and spatial proteomics (collaboration with A. Keeler lab) to understand the immune response and neuronal dysregulation that cause TMDs. We aim to use these novel approaches to discover disease- and symptom-modifying therapies.